Antibody Discovery Immunology - Research Areas

ANTIBODY DISCOVERY SOLUTIONS

From Discovery to Pre-Clinical Development

INTRODUCTION

ANTIBODY DISCOVERY WORKFLOW

STEP 1. LIBRARY GENERATION

STEP 2. LEAD IDENTIFICATION

STEP 3. LEAD OPTIMIZATION

STEP 4. PRE-CLINICAL DEVELOPMENT

THE GENEWIZ DIFFERENCE

CONTACT GENEWIZ

INTRODUCTION

Antibody-based therapeutics have entered the center stage of drug discovery as a result of a major shift in focus from small molecules to a broader portfolio containing both protein and chemical therapeutic agents. The field is benefiting from both an increased understanding of the mechanistic basis of antibody-derived therapeutics and the development of sophisticated technologies to derive safe and targeted biotherapeutics.

ANTIBODY DISCOVERY WORKFLOW

GENEWIZ offers the latest sequencing technologies and customizable synthetic DNA solutions to expedite your discovery process while keeping the cost low.

Check out GENEWIZ antibody solutions below to help you with each step of the discovery process.

Step 1: Library Generation

Synthetic DNA Libraries

provide highly diverse synthetic variant and combinatorial libraries with unprecedented flexibility to customize amino acid diversity to optimize your antibody discovery process.

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Diversity Assessment

via Amplicon Sequencing provides a comprehensive diversity analysis of your synthetic antibody DNA libraries.

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Step 2: Lead Identification

PCR + Sanger Assay

offers a full-service solution to facilitate the screening and confirmation of heavy chain/ light chain sequences.

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Direct Colony Sequencing

enables rapid phage analysis of isolated antibody clones after a bio-panning affinity selection.

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Amplicon Sequencing

offers identification of highly diverse leads after bio-panning enrichment.

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Immuno-Profiling

provides comprehensive analysis of in vivo repertoires after immunization.

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Step 3: Lead Optimization

Antibody DNA Synthesis

offers fully codon-optimized synthetic antibody constructs for recombinant antibody expression starting at just 6 business days.

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Colony Sequencing + Plasmid DNA Prep

offers a full-service solution to directly sequence bacterial clones followed by large-scale DNA preparation for recombinant antibody expression.

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Genome Editing and Engineering

offers a wide range of synthetic DNA solutions and sequencing-based solutions for creating transgenic cell lines.

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Long Single-Stranded DNA Synthesis

enables CRISPR-mediated gene knock-in to integrate recombinant V(D)J region to generate transgenic models for antibody production.

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Step 4: Pre-Clinical Development

GLP-Compliant Sequencing

of antibody-producing cell lines for FDA level submissions and confirmation of manufactured cell banks throughout the clinical pipeline.

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GLP-Compliant Plasmid Prep Services

offer a range of DNA preparation solutions to accelerate research and pre-clinical development for antibody drug discovery.

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Whole Genome Sequencing

provides a comprehensive validation of antibody-expressing cell lines on multiple sequencing platforms.

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THE GENEWIZ DIFFERENCE

Stringent Quality Control

Optimized workflows and technical expertise produce consistent results with best-in-class quality. GLP, CLIA, and CAP services are available.

Industry-leading Turnaround Time

DNA sequencing and synthesis delivered when you need it with expedited options for many services.

Unparalleled Technical Support

Ph.D.-level consultation provides guidance before, during, and after the project.

Partner of Choice

Over 600 pharmaceutical and biotechnology companies have trusted us with their projects.

CONTACT GENEWIZ

Ph.D.-level experts are available to discuss your project. Call us today at 877-436-3949.

Next Generation Sequencing • Ext. 1 • ngs@genewiz.com

Sanger Sequencing • Ext. 2 • dnaseq@genewiz.com

Synthetic DNA Solutions • Ext. 3 • pm@genewiz.com

Molecular Genetics • Ext. 3350 • molgen@genewiz.com

GLP-Compliant Services • Ext. 3350 • regulatory@genewiz.com

INTRODUCTION

ANTIBODY DISCOVERY WORKFLOW

Step 1: Library Generation

Step 2: Lead Identification

Step 3: Lead Optimization

Step 4: Pre-Clinical Development

THE GENEWIZ DIFFERENCE

CONTACT GENEWIZ

Azenta Life Sciences Headquarters