Featured Application: Antibody Development

The success of an in-vitro antibody discovery and development program is contingent on the diversity of functional candidates as well as the ability to enhance favorable characteristics. Choose Azenta’s combinatorial or trimer-controlled libraries to expedite your antibody discovery and development program while keeping the cost low.

• Combinatorial DNA libraries A powerful tool for determining and optimizing biomolecule function from a parent sequence. By coupling these libraries with a screening technology such as phage display, it becomes possible for researchers to both develop and test an immense number of mutant variants in a short time. Depending on the research goals, budget, and timeline, different mutagenesis techniques can be used to create variants. The below table compares three industry standard approaches. 

• Trimer-controlled libraries: An effective tool that significantly reduces screening efforts compared to conventional mutagenesis methods, empower researchers with the most accuracy, precision, and control as compared to other combinatorial DNA library techniques because of the extra synthetic effort devoted to restricting codon building blocks. Download the case study below to learn why researchers at a large bio-pharmaceutical company chose Azenta combinatorial trimer-controlled synthesis of antibody libraries to obtain a highly accurate mutant library.